The CrCl rate approximates the calculation of GFR since the glomerulus freely filters creatinine. Its production in the body is dependent on muscle mass. GFR approximation using Creatinine ClearanceĬreatinine is a breakdown product of dietary meat and creatine phosphate found in skeletal muscle. GFR = * urine flow (mL/min)/, where X is a substance that is completely excreted. Below is the equation used to determine GFR, typically recorded in volume per time (e.g., mL/min): This mass divided by the plasma concentration is equivalent to the volume of plasma from which the mass was originally filtered. For such a given substance, the urine concentration multiplied by the urine flow equals the mass of the substance excreted during the time of urine collection. The clearance rate for a given substance equals the GFR when it is neither secreted nor reabsorbed by the kidneys. The filtration in the kidney is dependent on the difference in high and low blood pressure created by the afferent (input) and efferent (output) arterioles, respectively. The GFR in the measurement of volume filtered through the glomerular capillaries and into the Bowman’s capsule per unit of time. Both CrCl and GFR can be measured using the comparative values of creatinine in blood and urine. It is a rapid and cost-effective method for the measurement of renal function. Creatinine clearance (CrCl) is the volume of blood plasma cleared of creatinine per unit time. Alternatively, the biochemical marker creatinine found in serum and urine is commonly used in the estimation of GFR. However, the use of inulin is invasive, time-consuming, and an expensive procedure. The gold standard measurement of GFR involves the injection of inulin and its clearance by the kidneys.

The glomerular filtration rate (GFR) describes the flow rate of filtered fluid through the kidneys. Determining the renal function status can predict kidney disease progression and prevent toxic drug levels in the body. The measurement of accurate renal function is vital for the routine care of patients.

Normal bun and creatinine range